To care for a Hoya crassipetiolata, provide it with bright, indirect light, water it when the top 1-2 inches of soil are dry to prevent root rot, and use a well-draining soil mix. This plant tolerates typical indoor humidity but appreciates higher levels. As a vining plant, it can benefit from a trellis or support to climb. Fertilize during the growing season and do not remove spent flower stalks, as it can rebloom.